von Willebrand's disease in pregnancy.
نویسنده
چکیده
Von Willebrand disease (vWD) is the most common inherited bleeding disorder. It is due to deficiency of von Willebrand factor (vWF) which may be either quantitative or qualitative. There are 3 types of vWD out of which Type III is the rarest but the most severe. We report a 27 years second gravida diagnosed with vWD in her index pregnancy. Though her antenatal period was uneventful, she developed complications in the perioperative period following a caesarean section. However, with a multidisciplinary team effort, the maternal and fetal outcome were favourable.
منابع مشابه
Pregnancy and delivery in women with von Willebrand's disease and different von Willebrand factor mutations.
BACKGROUND Pregnancy in von Willebrand's disease may carry a significant risk of bleeding. Information on changes in factor VIII and von Willebrand factor and pregnancy outcome in relation to von Willebrand factor gene mutations are very scanty. DESIGN AND METHODS We examined biological response to desmopressin, changes in factor VIII and von Willebrand factor and pregnancy outcome in a cohor...
متن کاملVon Willebrand's disease and pregnancy.
Seven new cases of pregnancy combined with von Willebrand's disease have been reported. Altogether the patients had 11 deliveries, and one abortion after 10 weeks' gestation. The diagnosis was based on the determination of the bleeding time, factor VIII coagulant activity (VIII C), factor VIII-related antigen (VIII RAg) and the ristocetin cofactor (VIII RCoF). Two of our 6 parturients showed pr...
متن کاملType IIB von Willebrand's disease: differential clearance of endogenous versus transfused large multimer von willebrand factor.
The abnormal multimeric composition of plasma von Willebrand factor in type IIB von Willebrand's disease is transiently corrected after infusion of 1-deamino-[8-D-arginine]-vasopressin. However, the larger multimers released into the circulation disappear more rapidly in these patients than in type I von Willebrand's disease or normals. We demonstrate that the larger multimers of normal von Wil...
متن کاملvon Willebrand's disease antigen II. A new plasma and platelet antigen deficient in severe von Willebrand's disease.
Factor VIII-related antigen (VIIIag) is deficient in plasma and platelets of patients with severe von Willebrand's disease. This study reports a second von Willebrand's disease antigen (vWagII), distinct from VIIIag, that is also deficient in the platelets and plasma of patients with severe von Willebrand's disease. VIIIag and vWagII are separable by molecular exclusion chromatography, sucrose ...
متن کاملVariant von Willebrand's disease and pregnancy.
The clinical course and coagulation profile of a pregnant patient with variant von Willebrand's disease were followed from the second trimester through puerperium. The clinical course was characterized by a normal delivery and absence of abnormal bleeding or need for replacement therapy. The coagulation profile demonstrated an increase in factor VIII procoagulant activity, factor-VIII-related a...
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ورودعنوان ژورنال:
- Obstetrics and gynecology
دوره 41 6 شماره
صفحات -
تاریخ انتشار 1950